A 51 year old femaile from Spring Hill driving a SUV was traveling eastbound on Corporate Blvd approaching Aerial Way. A 30 year old male in a pick-up truck was traveling westbound on Corporate Blvd approaching Aerial Way. For reasons unknown, The driver of the SUV crossed over the double yellow center line. As a result, the left front of the SUV struck the left front of pick up truck. The driver of pickup was pronounced deceased on the scene. The 51 year old female of the SUV was transported to a local hospital with incapacitating injuries. The driver of the pickup was not wearing a seatbelt. The intersection was closed for several hours.